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KMID : 0356920070520040443
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Korean Journal of Anesthesiology
2007 Volume.52 No. 4 p.443 ~ p.448
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Rocuronium-induced Neuromuscular Block after Long Pretreatment of Magnesium Sulfate in Rabbits
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Min Hyoung-Ki
Kim Kyo-Sang
Lee Gurn-Seung
Min Hyoung-Ki
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Abstract
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Background: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. This study was been conducted to evaluate the potency and time course of rocuronium-induced neuromuscular block after prolonged pretreatment with MgSO4 in rabbits.
Methods: Forty rabbits were randomly assigned to two groups; the control group: normal saline 0.1 ml/kg sq for 6 weeks; and the study group: 50% MgSO4 60 mg/kg sq for 6 weeks. The dose-response relationships of rocuronium were studied during thiopental anesthesia in twenty rabbits. Each group received rocuronium 40, 60 and 80μg/kg rocuronium, respectively, and the time course of rocuronium, at 0.6 mg/kg, evaluated in the twenty rabbits in each group.
Results: The mean serum magnesium concentration were 2.3?2.6 and 3.3?3.9 mEq/L in the control and study groups, respectively (P ＜ 0.001). The calculated ED50s for rocuronium were 52.7 and 61.2μg/kg in the control and study groups, respectively (P ＜ 0.05). The times after rocuronium administration until the 95% twitch recovery were 49.3 and 34.8 min in the control and study groups, respectively (P ＜ 0.05).
Conclusions: Rocuronium, following prolonged MgSO4 pretreatment had a decreased effect and short duration of action compared with the control, for which increased doses of nondepolarizing muscle relaxants would be required to obtain a similar effect. Korean J Anesthesiol 2007; 52: 443∼8)
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KEYWORD
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MgSO4, pharmacodynamics, rabbits, rocuronium
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